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KMID : 1007520040130010080
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Food Science and Biotechnology
2004 Volume.13 No. 1 p.80 ~ p.84
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Resveratrol Induces Apoptosis in SW480 Human Colon Cancer Cell Lines
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Lee, Hyun Sook
Sur, Eun Young/Kim, Woo Kyoung
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Abstract
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Resveratrol, (3,4^(†), 5-trans-trihydroxystilbene), a phytoalexin present in fruits and vegetables, possesses potent anti-inflammatory and anti-tumor activities. Effects of resveratrol on protein expressions of caspase-3, Bcl-2, Bax, total Akt and phosphorylated Akt, ErbB2, and erbB3 in SW480 human colon cancer cell were investigated using SW480 cells cultured with various concentrations (0, 2.5, 5, 7.5, and 10 ㎛) of resveratrol. Resveratrol inhibited colon cancer cell growth in a dose-dependent manner (p<0.05), and increased caspase-3 expression. Bax expression was significantly increased and Bcl-2 levels were dose-dependently decreased in resveratrol-treated cells (p<0.05). Phosphorylated Akt, total Akt, ErbB2, and ErbB3 levels were markedly lower in 5 ㎛ resveratrol-treated cells (p<0.05). Results reveal resveratrol inhibits cell growth and induces apoptosis in SW480 human colon cancer cell lines via ErbB2/Akt signal pathway.
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